https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 The risk of secondary progressive multiple sclerosis is geographically determined but modifiable https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54611 Wed 06 Mar 2024 10:38:32 AEDT ]]> Aspect-controlled spatial and temporal soil moisture patterns across three different latitudes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43471 Tue 20 Sep 2022 09:59:19 AEST ]]> Oceanographic boundaries constrain microbial diversity gradients in the South Pacific Ocean https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43319 Thu 15 Sep 2022 14:29:31 AEST ]]> Latitudinal variation in incidence and type of first central nervous system demyelinating events https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10630 Sat 24 Mar 2018 08:13:48 AEDT ]]> Heavy ion mass loading of the geomagnetic field near the plasmapause and ULF wave implications https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:282 Sat 24 Mar 2018 07:42:51 AEDT ]]> The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28462 p = 0.02). Furthermore, the outcome of patients negative for CSF-specific OCB was significantly better in comparison to the OCB positive patients, as assessed by Expanded Disability Status Scale change (p < 0.001). Conclusions: The results of this study indicate that latitude could explain some of the inconsistencies in OCB status reported in different populations. The study confirms that OCB positivity in MS is associated with a worse long-term prognosis.]]> Sat 24 Mar 2018 07:39:33 AEDT ]]> Higher latitude is significantly associated with an earlier age of disease onset in multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29942 -23). A reciprocal relationship was seen for ambient ultraviolet radiation (UVR), with a significantly increasing AAO for patients with MS per each quartile increment of ambient UVR (p=1.56×10-17). We found that the AAO of female patients was ~5 months earlier than male patients (p=0.002). AAO of progressive-onset patients with MS were ~9 years later than relapsing-onset patients (p=1.40×10-265). Conclusions: An earlier AAO in higher latitude regions was found in this worldwide European-descent cohort and correlated inversely with variation in latitudinal UVR. These results suggest that environmental factors which act at the population level may significantly influence disease severity characteristics in genetically susceptible populations.]]> Sat 24 Mar 2018 07:31:01 AEDT ]]>